People with periodontitis (gum disease) are at higher risk of experiencing major cardiovascular events, according to new research from Forsyth Institute and Harvard University scientists and colleagues.
In a longitudinal study published recently in the Journal of Periodontology, Dr Thomas Van Dyke at Forsyth, Dr Ahmed Tawakol of Massachusetts General Hospital, and their collaborators showed that inflammation associated with active gum disease was predictive of arterial inflammation, which can cause heart attacks, strokes, and other dangerous manifestations of cardiovascular disease.
For the study, researchers performed positron emission tomography and computer tomography (PET and CT) scans on 304 individuals to view and quantify inflammation in the arteries and gums. In follow-up studies approximately four years later, 13 of those individuals developed major adverse cardiovascular events. Presence of periodontal inflammation was shown to be predictive of cardiovascular events, even after researchers controlled for all other risk factors, such as smoking, high blood pressure, obesity, and diabetes.
Importantly, researchers found that bone loss from prior periodontal disease was not associated with cardiovascular events. Patients that did not have actively inflamed gums had a lower risk of cardiovascular disease – even if those individuals had a prior history of periodontal disease.
Researchers hypothesise that local periodontal inflammation activates and mobilises cells signalling through bone marrow, which triggers the inflammation of arteries, leading to adverse cardiac events.
While the study sample size is relatively small, Van Dyke said the observation is significant and should be studied in a much larger population. For people with active gum disease, seeking treatment could potentially prevent a dangerous a cardiac event.